The Geography of Human Flourishing project explores Harvard’s archive of 10 billion geolocated tweets (from 2010 to mid-2023) through the lens of the six domains of human flourishing defined by the Global Flourishing Study (GFS). Using fine-tuned large language models (LLMs) at scale, the project extracts 46 indicators corresponding to these domains to create high-resolution spatio-temporal datasets. For the I-GUIDE Spatial AI Challenge, the project focuses on a U.S.-based subset of 2.2 billion geolocated tweets to develop interactive dashboards and scalable analytical workflows that examine patterns of human flourishing across geographic contexts. This talk will present the dataset analyzed, methodological approach, key findings, lessons learned, and proposed next steps.